Socs1 CLIA Kit for Mouse(Mus musculus) | EIAab.comSocs1 CLIA Kit for Mouse(Mus musculus)

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Socs1 (Gene name),

Suppressor of cytokine signaling 1 (Protein name ), SOCS1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Socs1(Cish1;Ssi1);

Protein name:

Suppressor of cytokine signaling 1(SOCS-1);

Alternative:

STAT-induced STAT inhibitor 1(SSI-1);JAK-binding protein(JAB);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domain to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with CUL2. Interacts with AXL and FGFR3.

Function:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.

Subcellular Location:

Nucleus Cytoplasmic vesicle Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Protein Attributes:

Sequence length:

212

Sequence:

50:

100:

150:

200:

212:

LRDYLSSFPF | QI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.130

KEGG:

mmu:12703

Pfam:

PF00017

SMR:

O35716

String:

O35716

Uniprot:

O35716

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ELISA Kit for Mouse SOCS-1

Cat.:

E1416h

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96T

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ELISA Kit for Mouse SOCS-1

Cat.:

E1416m

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96T

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ELISA Kit for Mouse SOCS-1

Cat.:

E1416r

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96T

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CLIA Kit for Mouse SOCS-1

Cat.:

U1416m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse SOCS-1

Cat.:

U1416h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse SOCS-1

Cat.:

U1416r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse SOCS-1

Cat.:

P1416Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse SOCS-1

Cat.:

P1416Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse SOCS-1

Cat.:

P1416Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse SOCS-1

Protein for Mouse SOCS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A family of cytokine-inducible inhibitors of signaling."
Starr R. , Willson T.A. , Viney E.M. , Murray L.J.L. , Rayner J.R. , Jenkins B.J. , Gonda T.J. , Alexander W.S. , Metcalf D. , Nicola N.A. , Hilton D.J.
Nature387:917-921(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thymus.
2.

"A new protein containing an SH2 domain that inhibits JAK kinases."
Endo T.A. , Masuhara M. , Yokouchi M. , Suzuki R. , Sakamoto H. , Mitsui K. , Matsumoto A. , Tanimura S. , Ohtsubo M. , Misawa H. , Miyazaki T. , Leonor N. , Taniguchi T. , Fujita T. , Kanakura Y. , Komiya S. , Yoshimura A.
Nature387:921-924(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Structure and function of a new STAT-induced STAT inhibitor."
Naka T. , Narazaki M. , Hirata M. , Matsumoto T. , Minamoto S. , Aono A. , Nishimoto N. , Kajita T. , Taga T. , Yoshizaki K. , Akira S. , Kishimoto T.
Nature387:924-929(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thymus.
4.

"SOCS-1 binds to multiple signaling proteins and suppresses Steel factor-dependent proliferation."
De Sepulveda P. , Okkenhaug K. , La Rose J. , Hawley R.G. , Dubreuil P. , Rottapel R.
EMBO J.18:904-915(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hematopoietic.
5.

"Regulation of SOCS-1 expression by translational repression."
Gregorieff A. , Pyronnet S. , Sonenberg N. , Veillette A.
J. Biol. Chem.275:21596-21604(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Skin.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
8.

"The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families."
Kamura T. , Sato S. , Haque D. , Liu L. , Kaelin W.G. Jr. , Conaway R.C. , Conaway J.W.
Genes Dev.12:3872-3881(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELONGIN BC COMPLEX;MUTAGENESIS OF LEU-175 AND CYS-179
9.

"The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation."
Zhang J.-G. , Farley A. , Nicholson S.E. , Willson T.A. , Zugaro L.M. , Simpson R.J. , Moritz R.L. , Cary D. , Richardson R. , Hausmann G. , Kile B.J. , Kent S.B.H. , Alexander W.S. , Metcalf D. , Hilton D.J. , Nicola N.A. , Baca M.
Proc. Natl. Acad. Sci. U.S.A.96:2071-2076(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ELONGIN BC COMPLEX
10.

"TRIM8/GERP RING finger protein interacts with SOCS-1."
Toniato E. , Chen X.P. , Losman J. , Flati V. , Donahue L. , Rothman P.
J. Biol. Chem.277:37315-37322(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM8
11.

"Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling."
Narazaki M. , Fujimoto M. , Matsumoto T. , Morita Y. , Saito H. , Kajita T. , Yoshizaki K. , Naka T. , Kishimoto T.
Proc. Natl. Acad. Sci. U.S.A.95:13130-13134(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
12.

"Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1."
Starr R. , Metcalf D. , Elefanty A.G. , Brysha M. , Willson T.A. , Nicola N.A. , Hilton D.J. , Alexander W.S.
Proc. Natl. Acad. Sci. U.S.A.95:14395-14399(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
13.

"Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction."
Nicholson S.E. , Willson T.A. , Farley A. , Starr R. , Zhang J.-G. , Baca M. , Alexander W.S. , Metcalf D. , Hilton D.J. , Nicola N.A.
EMBO J.18:375-385(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
14.

"The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop."
Yasukawa H. , Misawa H. , Sakamoto H. , Masuhara M. , Sasaki A. , Wakioka T. , Ohtsuka S. , Imaizumi T. , Matsuda T. , Ihle J.N. , Yoshimura A.
EMBO J.18:1309-1320(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INHIBITION OF JAK2 KINASE ACTIVITY;MUTAGENESIS OF HIS-55; PHE-56; ARG-57; THR-58; PHE-59; ARG-60; SER-61; HIS-62; ASP-64; TYR-65 AND ARG-105
15.

"A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box."
Hanada T. , Yoshida T. , Kinjyo I. , Minoguchi S. , Yasukawa H. , Kato S. , Mimata H. , Nomura Y. , Seki Y. , Kubo M. , Yoshimura A.
J. Biol. Chem.276:40746-40754(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF PHE-59
16.

"Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation."
Seki Y. , Hayashi K. , Matsumoto A. , Seki N. , Tsukada J. , Ransom J. , Naka T. , Kishimoto T. , Yoshimura A. , Kubo M.
Proc. Natl. Acad. Sci. U.S.A.99:13003-13008(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
17.

"Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms."
Ueki K. , Kondo T. , Kahn C.R.
Mol. Cell. Biol.24:5434-5446(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INHIBITION OF INSR KINASE ACTIVITY;INTERACTION WITH INSR

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